Dr. John Lee, M.D.
Answers Your Questions about Natural Progesterone
How do I know if I should
use natural progesterone?
If you have PMS Symptoms.
Symptoms occur consistently a week to 10 days before
the period and stop with or shortly thereafter.
If you have Estrogen Dominance symptoms. These
are water retention, breast swelling, fibrocystic
breast, uterine fibroid, loss of libido, mood swings,
depression, craving for sweets, and weight gain
with fat deposited at hips and thighs.
If you have Menopausal symptoms. Estrogen continues
to be produced from the fat in cells even after
menopause; however, progesterone production virtually
ends. Hot flashes are the most prominent symptoms
If you are over 50. Women older than 50 should
use natural progesterone cream to prevent osteoporosis.
Where should I apply natural
Natural progesterone (derived from the Mexican wild
yam root and/or soy) in a moisturizing cream is applied
to the face, hands, chest, abdomen, inner arms, inner
thighs, or soles of feet. The cream is readily absorbed
and leaves no trace after a few minutes. During absorption,
the cream bypasses the liver and goes to specific
receptor sites where progesterone is needed. When
action is completed, residue is excreted from the
body by the liver with no toxic effects. Relative
need for progesterone and the absorption rate vary
When do I use natural progesterone cream?
If you are still menstruating, use ½ teaspoon of
cream twice a day after ovulation (generally 12-14
days from the first day of menstrual flow) until
day 26. You do not use natural progesterone while
you are menstruating; however, if you experience
menstrual cramps, try rubbing cream on lower abdomen.
If you have menopausal symptoms and are still menstruating,
use ½ teaspoon cream twice per day beginning with
the 10-12th day from day 1 of menstruation until
day 26. (After 3 months, start using cream 12-14
days from day 1 of menstruation until day 26.)
If you have menopausal symptoms and are not menstruating,
have osteoporosis or want to prevent osteoporosis,
use cream based on calendar month. Start using ½
teaspoon twice per day on 8th of each month and
continue to end of the month.
It is important to stop using the cream at least five
days each month; preferably seven.
Please note: Everyone is different. Some
women require more progesterone cream to help alleviate
symptoms; others can use less. For the first 3 months,
use one 2-oz. tube per month. Then try cutting back
on the amount of natural progesterone to 1/8 tsp. twice
per day. If symptoms return, resume previous usage.
If I'm already taking hormones from my doctor, why should
I switch to natural hormones?
Natural hormones are simply an alternative to hormone
replacement therapy. Synthetic progesterone (progestins)
has many side effects, and synthetic estrogen can
endanger your health-especially if taken without any
progesterone. If someone is taking both synthetic
estrogen and progestins, a gradual step may be to
substitute natural progesterone cream, gradually backing
off synthetic estrogen. Reduce estrogen use by one-half
and continue to reduce over 90 days until discontinued
Can natural progesterone
be used during pregnancy?
In his book, Premenstrual Syndrome & You, Neils
H. Lauersen, M.D., from Mount Sinai Medical Center
in New York, states that natural progesterone may
be helpful to maintain pregnancy. The cream is not
only safe for use during pregnancy but is recommended.
From conception to delivery, apply primarily to
abdomen, breast, low back, and upper thighs (where
it will tend to help prevent the skin from stretching).
For the first six months of pregnancy, use and average
of ½ to ¾ teaspoon 2 to 3 times per day. During
the last trimester, apply one teaspoon 2 or 3 times
per day. Discontinue at delivery and resume again
at a level of twice per day stating one month after
The cream is also useful for post-partum depression,
which many women experience after childbirth.
Can young girls use natural
Yes. Low estrogen levels can adversely affect the
general health of girls between the ages of 9 and
13. For a year or more before the onset of menstruation,
blood calcium are so low that young girls often
develop symptoms associated with menarche, which
are usually accepted as normal behavior: "emotional
outbursts", "irritable and temperamental behavior",
and "compulsive consumption of sweets".
During puberty, the maturing ovaries require calcium
to produce estrogen, thus diverting calcium from
metabolic requirements. Introducing natural progesterone
at this time will alleviate most of the symptoms
mentioned above. Continued use of natural progesterone
will maintain a high level of wellness with few
or no PMS complaints.
How does natural differ
from synthetic progesterone?
Natural progesterone, a cholesterol derivative,
comes from Mexican yams or soybeans. It matches
exactly the chemical formulation of the body's own
progesterone and thus causes no side effects.
Manufacturers of synthetic progesterone alter the
chemical makeup of progesterone in order to create
progestins. Progestins in their altered molecular
structure may cause many side effects, such as birth
defects or abortion, fluid retention, epilepsy,
migraine, asthma, cardiac or kidney dysfunction,
Can natural progesterone
help with endometriosis or fibrocystic breast?
One common factor in both of these conditions is
a higher level of circulating estrogen. Progesterone-which
helps to normalize all other endocrine and hormonal
activity in the body-may help to clear these conditions
by helping to lower the level of estrogen.
Do natural hormones alleviate
Vaginal dryness, which can occur in women of all
ages for various reasons, affects primarily post-menopausal
women. Natural hormones in a cream base, used intravaginally,
have been successful in treating vaginal dryness and
vulvar atrophy associated with aging.
Should estrogen be used
Definitely not. It is important that natural progesterone
be used with any form of estrogen. Estrogen without
progesterone can cause endometrial and vaginal carcinomas.
Estrogen blocks thyroid activity and causes water
retention; it can cause fibrocystic breast disease
and even fibroid tumors and cysts in the ovary area.
Do I need a prescription for natural hormones?
No. Natural hormones in a cream or oil base come
from Mexican yams and/or soybeans-technically food
If I use natural hormones
after menopause begins, will I start menstruating again?
Occasionally, upon beginning use of natural hormone
supplement, a post-menopausal woman could experience
some breakthrough bleeding, or a "period". This perfectly
normal response should not cause alarm. The progesterone
is simply causing the body to rid itself of excess
stored estrogen, which can sometimes stimulate a uterine
shedding-thus breakthrough bleeding. If bleeding occurs
for longer than several months, a woman should consult
How does natural progesterone affect excessive facial
hair, especially above my upper lip?
Excess facial hair, which may require occasional
shaving, and body hair is a condition called "hirsutism".
It indicates a hormonal imbalance among estrogen,
testosterone (the dominant male hormone), and progesterone.
Progesterone acts as a regulator for the entire endocrine
system. A woman who has the hirsute problem probably
has PMS too. Both menopausal and menstruating women
have reported that facial hair (and body hair) decreased
or completely disappeared after three to six months
of regular application of cream twice a day. Natural
progesterone is needed for proper hormonal balance.
Is natural progesterone
useful after hysterectomy, oophorectomy, or menopause?
Yes. Many women experience hot flashes following
premenopausal hysterectomy (removal of uterus) or
oophorectomy (complete removal of ovaries), as well
as at the beginning of the natural onset of menopause.
The cream, which contains natural progesterone, is
reported to be effective for relieving symptoms of
hot flashes. Most women have reported a complete cessation
of flushing within 3 to 8 weeks.
Is natural progesterone
indicated for osteoporosis?
Many medical "authorities" tell post-menopausal
patients that osteoporosis is inevitable if they
live long enough. A physician in Mill Valley California,
John R. Lee, has proven that this often-repeated
statement is simply untrue. The results of his ongoing
clinical study with 100 women are noteworthy. Women
who used natural progesterone cream from 6 to 48
months all experienced new bone density ranging
from 5 to 40 percent.
His results also show that therapy is successful
even several decades after menopause.
One of his patients, age 82, who has been using
natural progesterone cream for four years, has gained
more than 40 percent new bone density, as proven
by dualphoton absorptiometry. Dr. Lee has proven
that osteoporosis is not only preventable, but in
most cases also reversible.
Can I use natural progesterone if my family has a history
of breast or uterine cancer?
Yes. Breast cancer and endometrial cancer occur in
tissues sensitive to gonadal hormones. Unopposed estrogen
is the only known cause of endometrial cancer, though
other factors may be involved. Estrogen, or at least
one or more of the various estrogens, may contribute
to breast cancer. Progesterone balances the estrogen
level in the body, thus lessening the risk.
Can men use natural progesterone?
Men over 45 can use natural progesterone. One benefit
is an increase in the libido. Progesterone is the
precursor of testosterone. Testosterone can stimulate
new bone formation, increasing bone density; a lack
of it can cause osteoporosis. Older men with rheumatoid
arthritis have reported relief from pain and swelling
after rubbing natural progesterone in a cream base
on their joints.